Generic placeholder image

Current Pediatric Reviews


ISSN (Print): 1573-3963
ISSN (Online): 1875-6336

New Insights into the Pathogenesis of and Long-Term Risks in Children with Henoch-Schonlein Purpura Nephritis

Author(s): Lavjay Butani and Keith K. Lau

Volume 4 , Issue 1 , 2008

Page: [58 - 65] Pages: 8

DOI: 10.2174/157339608783565789

Price: $65


Renal involvement is the major factor determining the long-term outcome of children with Henoch-Schonlein Purpura (HSP) nephritis. The precise incidence of adverse outcomes is debatable; moreover, there are conflicting data on the validity of prognostic factors for predicting adverse outcome in children with HSP nephritis. Difficulties in prognostication are compounded by lack of non-invasive diagnostic methods in children suspected of having HSP. The purpose of this article is to review recent data evaluating the role of serum galactose-deficient IgA in the pathogenesis of HSP nephritis and its potential role as a non-invasive diagnostic tool. Recent studies evaluating the role of prognostic markers and the risk of adverse long-term outcomes in children with HSP nephritis are also described. HSP nephritis, although relatively benign in most children, can lead to significant chronic kidney disease in a subset of children, especially on very longterm follow-up. Health-care providers need to be aware of this and tailor appropriate follow-up and screening tests to identify early signs of renal functional deterioration, so that therapies that can retard the rate of progression can be instituted early.

Keywords: Henoch-Schonlein Purpura Nephritis, children, aberrantly glycosylated IgA1, pathogenesis, prognosis

Rights & Permissions Print Export Cite as
© 2022 Bentham Science Publishers | Privacy Policy