Abstract
In asthma, bronchial mucosal tissues are chronically infiltrated by activated inflammatory cells (mainly lymphocytes and eosinophils) that have the capacity to produce a wide range of cytokines (IL-4, IL-5) and mediators (leucotrienes, prostaglandins, etc.). These molecules may significantly change the functional and phenotypic behavior of resident cells (epithelial cells, fibroblasts, smooth muscle cells, etc.) In addition to their role in tissue repair, resident cells are an important source of cytokines. They play an active role in modulating the immune response, suggesting that they may be involved in the maintenance and chronicity of the inflammatory response. These cells are also involved in structural changes observed in asthma, such as subepithelial fibrosis [3]. The alteration in the structure of the bronchial tree appears to be one of the factors involved in the persistence of bronchial hyperreactivity [4]. This review will focus on the role of structural cells on airway remodeling and their response to asthma medication.
Keywords: Asthma, airway remodeling, epithelium repair, fibroblasts, asthma medication
Current Respiratory Medicine Reviews
Title: The Role of Structural Cells on Airway Remodeling and Their Response to Asthma Medication
Volume: 4 Issue: 1
Author(s): Jamila Chakir, Abdelhabib Semlali and Eric Jacques
Affiliation:
Keywords: Asthma, airway remodeling, epithelium repair, fibroblasts, asthma medication
Abstract: In asthma, bronchial mucosal tissues are chronically infiltrated by activated inflammatory cells (mainly lymphocytes and eosinophils) that have the capacity to produce a wide range of cytokines (IL-4, IL-5) and mediators (leucotrienes, prostaglandins, etc.). These molecules may significantly change the functional and phenotypic behavior of resident cells (epithelial cells, fibroblasts, smooth muscle cells, etc.) In addition to their role in tissue repair, resident cells are an important source of cytokines. They play an active role in modulating the immune response, suggesting that they may be involved in the maintenance and chronicity of the inflammatory response. These cells are also involved in structural changes observed in asthma, such as subepithelial fibrosis [3]. The alteration in the structure of the bronchial tree appears to be one of the factors involved in the persistence of bronchial hyperreactivity [4]. This review will focus on the role of structural cells on airway remodeling and their response to asthma medication.
Export Options
About this article
Cite this article as:
Chakir Jamila, Semlali Abdelhabib and Jacques Eric, The Role of Structural Cells on Airway Remodeling and Their Response to Asthma Medication, Current Respiratory Medicine Reviews 2008; 4 (1) . https://dx.doi.org/10.2174/157339808783497783
DOI https://dx.doi.org/10.2174/157339808783497783 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
Call for Papers in Thematic Issues
Chronic obstructive pulmonary disease (COPD) from childhood to adulthood: from the past to the future
Chronic obstructive pulmonary disease (COPD) is one of the three leading causes of death worldwide, with a major prevalence in low- and middle-income countries, resulting in a high social and economic cost. It is a heterogeneous respiratory disease, treatable and preventable, that causes persistent and often progressive airway obstruction in ...read more

- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Development of a Gold Nanoparticle-labeled Sandwich Format Lateral Flow Immunoassay Kit for the Detection of Tropical House Dust Mite Suidasia pontifica
Protein & Peptide Letters Surfactant Protein A - From Genes to Human Lung Diseases
Current Medicinal Chemistry Using Small Molecule GSK3β Inhibitors to Treat Inflammation
Current Medicinal Chemistry Effects of Exercise on Anxiety and Depression Disorders: Review of Meta- Analyses and Neurobiological Mechanisms
CNS & Neurological Disorders - Drug Targets Antioxidants in the Practice of Medicine; What Should the Clinician Know?
Cardiovascular & Hematological Disorders-Drug Targets Epigenetic Regulation in Particulate Matter-Mediated Cardiopulmonary Toxicities: A Systems Biology Perspective
Current Pharmacogenomics and Personalized Medicine The Therapeutic Potential of Adenosine Triphosphate as an Immune Modulator in the Treatment of HIV/AIDS: A Combination Approach with HAART
Current HIV Research Modulation of PMN-Endothelial Cells Interactions by Cyclic Nucleotides
Current Pharmaceutical Design Probiotics as an Alternative Strategy for Prevention and Treatment of Human Diseases: A Review
Inflammation & Allergy - Drug Targets (Discontinued) Quality of Life Questionnaires for Children With Bronchial Asthma at Jordan University Hospital: An Observational Study
Current Respiratory Medicine Reviews Chitosan-Based Nanocarriers for Pulmonary and Intranasal Drug Delivery Systems: A Comprehensive Overview of their Applications
Current Drug Targets G-Protein Coupled Receptors (GPCRs): A Comprehensive Computational Perspective
Combinatorial Chemistry & High Throughput Screening Kinase Inhibitors with Redox and Anti-inflammatory Activities
Current Topics in Medicinal Chemistry Recent Advances in Coumarins and 1-Azacoumarins as Versatile Biodynamic Agents
Current Medicinal Chemistry Antifungal Potential of Alkaloids As An Emerging Therapeutic Target
Current Drug Targets Significance of Hepatoprotective Liver Specific Targeted Drug Delivery: A Review on Novel Herbal and Formulation Approaches in the Management of Hepatotoxicity
Current Drug Targets On the Genetics of Innate Immunity in Crohns Disease
Current Genomics Editorial : (Thematic issue: Critical Appraisal of Ischemic Stroke Pathophysiology: Road to Cerebral Resuscitation? Part II)
Current Medicinal Chemistry Apoptosis in the Homeostasis of the Immune System and in Human Immune Mediated Diseases
Current Pharmaceutical Design Pharmacogenomics and Severe Infections: The Role of the Genomes of Both the Host and the Pathogen
Current Pharmacogenomics