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Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

In Silico Modulation of HMGN-1 Binding to Histones and Gene Expression by Interplay of Phosphorylation and O-GlcNAc Modification

Author(s): Nasir-ud-Din, Ishtiaq Ahmad, Tehmina S. Khan, Daniel C. Hoessli, Evelyne Walker-Nasir, Afshan Kaleem, Abdul R. Shakoori, Tehmina S. Khan, Daniel C. Hoessli and Abdul R. Shakoori

Volume 15, Issue 2, 2008

Page: [193 - 199] Pages: 7

DOI: 10.2174/092986608783489607

Price: $65


Utilizing different computational methods; phosphorylation, O-GlcNAc modification and Yin Yang sites are predicted in HMGN-1. Prediction results suggest that interplay of phosphorylation and O-GlcNAc modification regulates binding and removal of HMGN-1 with the nucleosome and its translocation from nucleus to cytoplasm and back to nucleus, consequently modulating gene expression.

Keywords: HMGN-1, chromatin, nucleosome, histones, post-translational modifications, Yin Yang sites

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