Generic placeholder image

Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Conformational Analysis Corresponding to Intra-Chain Disulfide Bridged Peptides in Proteins of Known Three-Dimensional Structure

Author(s): Kunchur Guruprasad and Settu Sridhar

Volume 15, Issue 2, 2008

Page: [160 - 187] Pages: 28

DOI: 10.2174/092986608783489562

Price: $65


We have carried out a systematic analysis in order to evaluate whether Intra-Chain Disulfide Bridged Peptides (ICDBPs) observed in proteins of known three-dimensional structure adopt structurally similar conformations as they may correspond to structural/functional motifs. 406 representative ICDBPs comprising between 3 to 17 amino acid residues could be classified according to peptide sequence length and main-chain secondary structure conformation into 146 classes. ICDBPs comprising 6 amino acid residues are maximally represented in the Protein Data Bank. They also represent the maximum number of main-chain secondary structure conformational classes. Individual ICDBPs in each class represent different protein superfamilies and correspond to different amino acid sequences. We identified 145 ICDBP pairs that had ≤ 0.5 Å root mean square deviation value corresponding to their equivalent peptide backbone atoms. We believe these ICDBPs represent structural motifs and possible candidates in order to further explore their structure/function role in the corresponding proteins. The common conformational classes observed for ICDBPs defined according to the main-chain secondary structure conformations; H (helix), B (residue in a isolated beta bridge), C (coil), E (extended beta strand), G (310 helix), I (pi helix), S (bend), T (hydrogen-bonded turn) were; “CHHH”, “CTTC”, “CSSS” and “CSSC” (for ICDBP length 4), “CSSCC” (length 5), “EETTEE”, “CCSSCC”, “CCSSSC” (length 6), “EETTTEE” (length 7), “EETTTTEE” (length 8), “EEEETTEEEE” (length 10), “EEEETTTEEEE” (length 11) and “EEEETTTTEEEE” (length 12).

Keywords: Protein Data Bank, intra-chain disulfide bridged peptides, structure analysis

Rights & Permissions Print Export Cite as
© 2023 Bentham Science Publishers | Privacy Policy