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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Pyranose N-Glycosyl Amines: Emerging Targets With Diverse Biological Potential

Author(s): Peter Norris

Volume 8, Issue 2, 2008

Page: [101 - 113] Pages: 13

DOI: 10.2174/156802608783378837

Price: $65


Interest in the chemistry and biological properties of non-nucleoside N-glycosidic compounds has gathered pace over the past several years; the occurrence of the N-glycoside moiety in glycoproteins and a range of active natural products has prompted the synthesis of a diverse spectrum of related materials with promising potential in medicinal chemistry. Particularly prominent has been the synthesis of novel N-glycosyl amides, 1,2,3-triazoles, and progress in the construction and diversification of natural products such as the mannopeptimycins and indolocarbazoles, each of which are discussed in this article.

Keywords: N-Glycosyl amine, N-glycosyl amide, N-glycosylated heterocycles

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