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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Targeting the Viral Nucleocapsid Protein in Anti-HIV-1 Therapy

Author(s): Yves Mely, Hugues de Rocquigny, Volodymyr Shvadchak, Sergiy Avilov, Chang Zhi Dong, Ursula Dietrich and Jean-Luc Darlix

Volume 8, Issue 1, 2008

Page: [24 - 35] Pages: 12

DOI: 10.2174/138955708783331603

Price: $65


The nucleocapsid protein (NC) plays seminal roles in HIV replication, thus representing a major drug target. NC functions rely on its two zinc-fingers and flanking basic residues. Zinc ejectors inhibit NC functions, but with limited specificity. New classes of molecules competing with NC or its viral nucleic acid and enzyme partners are reviewed here.

Keywords: NCp7, zinc ejector, library, HIV, structure, peptidomimetic, aptamer, intercalator

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