Abstract
In order to get insight into the trypanocidal mechanism of action of a series of 5-nitrofuryl containing hiosemicarbazones some studies related to their bioreduction were performed. Electron spin resonance spectra of radicals generated in T. cruzi by compounds bioreduction were analyzed. Three different patterns of ESR signals were observed for the different assayed compounds. These results were in agreement with the changes in the T. cruzi-oxygen uptake promoted by these compounds. On the other hand, free-radical scavenger properties, measured as oxygen radical absorbance capacity (ORAC), did not seem to correlate with the trypanocidal activity.
Keywords: Chagas disease, 5-nitrofuryl containing thiosemicarbazones, ORAC, ESR
Medicinal Chemistry
Title: Insight into the Bioreductive Mode of Action of Antitrypanosomal 5- Nitrofuryl Containing Thiosemicarbazones
Volume: 4 Issue: 1
Author(s): D. Gambino, L. Otero, J. D. Maya, A. Morello, C. Rigol, G. Barriga, J. Rodriguez, C. Folch, E. Norambuena, M. Gonzalez, C. Olea Azar and H. Cerecetto
Affiliation:
Keywords: Chagas disease, 5-nitrofuryl containing thiosemicarbazones, ORAC, ESR
Abstract: In order to get insight into the trypanocidal mechanism of action of a series of 5-nitrofuryl containing hiosemicarbazones some studies related to their bioreduction were performed. Electron spin resonance spectra of radicals generated in T. cruzi by compounds bioreduction were analyzed. Three different patterns of ESR signals were observed for the different assayed compounds. These results were in agreement with the changes in the T. cruzi-oxygen uptake promoted by these compounds. On the other hand, free-radical scavenger properties, measured as oxygen radical absorbance capacity (ORAC), did not seem to correlate with the trypanocidal activity.
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Cite this article as:
Gambino D., Otero L., Maya D. J., Morello A., Rigol C., Barriga G., Rodriguez J., Folch C., Norambuena E., Gonzalez M., Azar Olea C. and Cerecetto H., Insight into the Bioreductive Mode of Action of Antitrypanosomal 5- Nitrofuryl Containing Thiosemicarbazones, Medicinal Chemistry 2008; 4 (1) . https://dx.doi.org/10.2174/157340608783331470
DOI https://dx.doi.org/10.2174/157340608783331470 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
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