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Current Vascular Pharmacology


ISSN (Print): 1570-1611
ISSN (Online): 1875-6212

Advanced Glycation and ROS: A Link between Diabetes and Heart Failure

Author(s): Armando Rojas, Enrique Mercadal, Hector Figueroa and Miguel A. Morales

Volume 6, Issue 1, 2008

Page: [44 - 51] Pages: 8

DOI: 10.2174/157016108783331312

Price: $65


Despite many advances achieved to date, heart failure (HF) remains a leading cause of morbidity and mortality. There is a widely-accepted consensus that HF and diabetes are strongly linked by at least 3 mechanisms: associated comorbidities, coronary atherosclerosis or a specific diabetic cardiomiopathy. For the last 2 mechanisms, advanced glycation end-products may contribute to trigger key processes relevant to HF by affecting cardiac function through cross-linking or receptor engagement. This review focuses on the main effects of advanced glycation end-products on cardiomyocytes and endothelial cell function. Some pharmacological approaches are also discussed.

Keywords: Advanced glycation, heart failure, glucose imbalance, diabetes, cardiomyocytes, oxidative stress

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