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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

A Convenient Synthesis of Quinolines via Ionic Liquid-Catalysed Friedlander Annulation

Author(s): Tao Zhou, Jian-Li Lin and Zhen-Chu Chen

Volume 5, Issue 1, 2008

Page: [47 - 50] Pages: 4

DOI: 10.2174/157017808783330261

Price: $65

Abstract

A convenient and green protocol for the synthesis of quinolines by Friedlander annulation using an acidic ionic liquid, ethylammonium nitrate, as both a catalyst and a reaction medium is reported. The reactions were performed at 45°C with moderate to excellent yields. The recovered ionic liquid could be reused for several cycles without any loss of activity.

Keywords: Ionic liquid, Friedlander reaction, quinoline


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