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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

A Facile Synthesis of Lipo-Chitopentaose Nodulation Factor

Author(s): G.-L. Huang and Kongliang Wong

Volume 4, Issue 8, 2007

Page: [588 - 589] Pages: 2

DOI: 10.2174/157017807782795475

Price: $65


We prepared the penta-N-acetyl-chitopentaose 2 by using recombinant Escherichia coli (E. coli) strains harboring the nodC gene (encoding chitooligosaccharide synthase) from Azorhizobium caulinodans. The deacetylase NodB removed the N-acetyl moiety from the nonreducing terminus of 2 to give tetra-N-acetyl-chitopentaose 3. N-Acylation of 3 with stearyl chloride was performed in DMF containing water and provided the corresponding lipo-chitopentaose nodulation factor 4.

Keywords: Lipo-chitopentaose nodulation factor, chemo-enzymatic synthesis, degradation velocity, chitinase

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