Generic placeholder image

Current Protein & Peptide Science


ISSN (Print): 1389-2037
ISSN (Online): 1875-5550

Functional Regulation of Hepatic Cytochrome P450 Enzymes by Physicochemical Properties of Phospholipids in Biological Membranes

Author(s): Taeho Ahn, Mihee Kim, Chul-Ho Yun and Han-Jung Chae

Volume 8, Issue 5, 2007

Page: [496 - 505] Pages: 10

DOI: 10.2174/138920307782411392

Price: $65


Knowledge regarding the regulation of hepatic cytochrome P450 (P450) is crucial to the fields of drug therapy and drug development, as well as to our understanding of the mechanisms underlying the metabolic activation of toxic and carcinogenic compounds. P450 is a membrane-anchored protein that shows a variety of interaction with membrane phospholipids, which affect the membrane topology and catalytic activities of the protein. In particular, anionic phospholipids, nonbilayer forming lipids, and the degree of saturation of the lipid fatty acyl chain play important roles in the functional regulation of P450, as well as in the bilayer structure of the membrane. However, despite the importance of phospholipids in the regulation of P450s, the interaction of the protein with membrane phospholipids, and the membrane properties induced by phospholipids which regulate P450, are unclear. In this review, we describe the effect of the physicochemical properties of the phospholipid constituents of biological membranes on hepatic P450 catalytic activity, membrane insertion (and/or penetration), and structural changes.

Keywords: Cytochrome P450, lipid-domain, membrane, nonbilayer, phospholipid

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy