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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Recent Advances in the Medicinal Chemistry of Polyamine Toxins

Author(s): Kristian Stromgaard, Kim Andersen, Povl Krogsgaard-Larsen and Jerzy W. Jaroszewski

Volume 1, Issue 4, 2001

Page: [317 - 338] Pages: 22

DOI: 10.2174/1389557013406738

Price: $65


This review describes the recent developments in the field of polyamine toxins, with focus on structure activity relationship investigations, including studies of importance of the polyamine moiety for biological activity, photolabeling studies using polyamine toxins as templates, as well as use of solid phase methods for the synthesis of polyamine toxins. The review is mainly concerned with effects of polyamine toxins on nicotinic acetylcholine receptors and ionotropic glutamate receptors.

Keywords: Polyamine Toxins, Synthesis, Argiope lobata, Nephilia clavata, Nephilia maculata, Dolomedes okefinokensis, Hebestatis theveniti, Hololenta curta, Araneidae, Philanthus triangulum

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