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Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Isolation and Structural Characterization of a Peptide from the Venom of Scorpion with Toxicity Towards Invertebrates and Vertebrates

Author(s): Gerardo Corzo, Elba Villegas and Terumi Nakajima

Volume 8, Issue 5, 2001

Page: [385 - 393] Pages: 9

DOI: 10.2174/0929866013409256

Price: $65


Using a methodology based on HPLC fractionation, mass spectrometry analysis, and microinjection guide-bioassays, a peptide with toxicity to both insects and mammals was isolated from the venom of the scorpion Leiurus quinquestriatus hebraeus, and named LqhIV (after LqhII and LqhIII[1]). The primary sequence, circular dichroism spectrum and three-dimensional structure simulation of LqhIV indicate that it contains similar structure to that of the group of alpha scorpion toxins.

Keywords: Leiurus quinquestriatus hebraeus, Androctonus australis, Leiurus quinquestriatus quinquestriatus, Hebraeus, Quinquestriatus

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