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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Viral Protein Functions Study by Affinity Modification

Author(s): O. V. Morozova and I. V. Safronov

Volume 1, Issue 3, 2001

Page: [283 - 291] Pages: 9

DOI: 10.2174/1389557013406945

Price: $65


The knowledge of virus reproduction is necessary to design new safe drugs for inhibition of infections. Ultra-violet irradiation of virus proteins with labeled virus genome fragments permits to identify specific nucleic acid binding proteins. Affinity modification of enzymes with nucleotide derivatives could help to determine NTP-binding proteins and those involved in viral genome replication. Photoreactive analogues of nucleic acids are among the tools used to detect elongation subunits of replicative complexes. Affinity modification approach has already resulted in successful treatment of virus diseases.

Keywords: Viral Genomes, Proteins, Infuenza Virus trasnscriptase, Hiv reverse transcriptase, Avian myeloblastosis

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