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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Designing HIV Integrase Inhibitors-Shooting the Last Arrow

Author(s): Mahindra T. Makhija

Volume 13, Issue 20, 2006

Page: [2429 - 2441] Pages: 13

DOI: 10.2174/092986706777935096

Price: $65


The arsenal of drugs in the fight against AIDS is rapidly diminishing as the HIV becomes resistant to the available reverse transcriptase and protease inhibitors. After killing millions all over the world, the virus is still on the rampage and hence the pharmaceutical industry is resorting to the development of inhibitors of integrase. This seems to be the last arrow in the quiver of potential drug leads to combat the deadly infection. Several classes of HIV integrase inhibitors have been reported to date; however, none is clinically useful. This review details the existing knowledge of the biological functions of the HIV-1 integrase with the focus on its available inhibitors, their disadvantages, and the current trends in designing novel compounds as antiintegrase.

Keywords: Acquired immunodeficiency syndrome (AIDS), human immunodeficiency virus (HIV), retroviral integrase, antiviral agent

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