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Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Production of Recombinant Human Calcitonin from Silkworm (B. Mori) Larvae infected by Baculovirus

Author(s): Guan-zhen Yang, Zhen-zhen Chen, Da-fu Cui, Bo-liang Li and Xiang-fu Wu

Volume 9, Issue 4, 2002

Page: [323 - 329] Pages: 7

DOI: 10.2174/0929866023408689

Price: $65


A synthetic modified gene encoding the human calcitonin analog (hmCT) was expressed by use of the baculovirus expression system. After injection with recombinant baculoviruses, the hmCT-GST fusion protein was produced within the silkworm larvae. The fusion protein was purified by affinity chromatography. Biological activity of hmCT for hypercalcemic effect was determined in normal rats.

Keywords: Human Calcitonin, hmCT-GST fusion, recombinant baculoviruses, silkworm larvae, hypercalcemic effect

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