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Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Crystallization and Preliminary X-Ray Diffraction Analysis of FKBP12 Complexed with a Novel Neurotrophic Ligand

Author(s): Pengyun Li, Liwei Wang, Yi Ding, Beili Wu, Cuiling Shu, Aihua Nie, Song Li, Beifen Shen and Zihe Rao

Volume 9, Issue 5, 2002

Page: [459 - 463] Pages: 5

DOI: 10.2174/0929866023408517

Price: $65


A novel neurotrophic ligand, (3R)-4-(p-Toluenesulfonyl)-1,4-thiazane-3-carboxylic acid-L-Leucine ethyl ester, has been complexed with FKBP12 and crystallized using the hanging-drop vapor-diffusion method. Crystals belong to P2 1 space group, with unit cell parameters a=41.2, b=29.6, c=41.5Å, β=114.0 . The crystals diffract to 1.8 Å resolution limit.

Keywords: FKBP12, (3R)-4-(p-Toluenesulfonyl)-1, 4-thiazane-3-carboxylic acid- L-Leucine, 000308, crystallization, ligand, complex, neurotrophic, X-ray

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