Antibiotic Activity of Reversed Peptides of A- Helical Antimicrobial Peptide, P18

Title: Antibiotic Activity of Reversed Peptides of A- Helical Antimicrobial Peptide, P18

Volume: 9 Issue: 5

Author(s): Si-Hyung Lee, Dong Gun Lee, Sung-Tae Yang, Yangmee Kim, Jae Il. Kim, Kyung-Soo Hahm and Song Yub Shin

Affiliation:

Keywords: P18, antimicrobial peptide, reversed peptide, antimicrobial activity, hemolytic activity

Abstract: P18 (KWKLFKKIPKFLHLAKKF-NH2), an α-helical antimicrobial peptide designed from cecropin Amagainin 2 hybrid, was known to have potent antimicrobial activity against bacteria as well as fungi without hemolytic activity. To find the peptides comparable or superior to the antimicrobial activity of P18, the two reversed peptides (Rev-1 and Rev-2) of P18 were designed and synthesized. These peptides were found to have similar antimicrobial activity against bacterial and fungal cells without hemolytic activity as compared with P18. Furthermore, a reversed peptide, Rev-2 was shown to have a two-fold higher activity in killing some bacterial cells than P18. Therefore, these results suggested that Rev-2 peptide seems to be an excellent candidate for developing novel peptide antibiotics.

Cite this article as:

Lee Si-Hyung, Lee Gun Dong, Yang Sung-Tae, Kim Yangmee, Kim Il. Jae, Hahm Kyung-Soo and Shin Yub Song, Antibiotic Activity of Reversed Peptides of A- Helical Antimicrobial Peptide, P18, Protein & Peptide Letters 2002; 9 (5) . https://dx.doi.org/10.2174/0929866023408535