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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Antibiotic Activity of Reversed Peptides of A- Helical Antimicrobial Peptide, P18

Author(s): Si-Hyung Lee, Dong Gun Lee, Sung-Tae Yang, Yangmee Kim, Jae Il. Kim, Kyung-Soo Hahm and Song Yub Shin

Volume 9, Issue 5, 2002

Page: [395 - 402] Pages: 8

DOI: 10.2174/0929866023408535

Price: $65

Abstract

P18 (KWKLFKKIPKFLHLAKKF-NH2), an α-helical antimicrobial peptide designed from cecropin Amagainin 2 hybrid, was known to have potent antimicrobial activity against bacteria as well as fungi without hemolytic activity. To find the peptides comparable or superior to the antimicrobial activity of P18, the two reversed peptides (Rev-1 and Rev-2) of P18 were designed and synthesized. These peptides were found to have similar antimicrobial activity against bacterial and fungal cells without hemolytic activity as compared with P18. Furthermore, a reversed peptide, Rev-2 was shown to have a two-fold higher activity in killing some bacterial cells than P18. Therefore, these results suggested that Rev-2 peptide seems to be an excellent candidate for developing novel peptide antibiotics.

Keywords: P18, antimicrobial peptide, reversed peptide, antimicrobial activity, hemolytic activity


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