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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Approaches for the Inhibition of Human Telomerase Based on the Use of Peptide Nucleic Acids and Hammerhead Ribozymes

Author(s): N. Zaffaroni, R. Villa, M. Pennati and M. Folini

Volume 3, Issue 1, 2003

Page: [51 - 60] Pages: 10

DOI: 10.2174/1389557033405458

Price: $65

Abstract

The ability of peptide nucleic acids and hammerhead ribozymes, which target different subunits of human telomerase, to efficiently inhibit the enzymes catalytic activity has been clearly demonstrated in several in vitro studies carried out in human immortalized and cancer cell lines. However, the actual efficacy of these molecules still needs to be validated in in vivo human tumor models, and such validation appears to be largely dependent on the development of reliable systems for their intracellular delivery.

Keywords: telomerase inhibitor, human telomerase, hammerhead ribozyme, peptide nucleic acid, htr


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