Abstract
While classical neuroleptics are characterized by dopamine D2 antagonism, this is also considered to be the cause of their neurological side effects. In recent years, novel antipsychotic drugs with improved efficacy, devoid of extrapyramidal effects are being developed. The mechanisms of action of these new atypical antipsychotics can be classified into three general groups: a) binding to D2 together with non-dopaminergic receptors, b) interaction with dopamine receptor subtypes other than D2 and c) selective binding to nondopaminergic systems, such as glutamatergic, sigma, neurotensin, and cannabinoid.
Keywords: Antipsychotic Drugs, D2 antagonism, dopamine receptor, neurotensin, glutamatergic, nondopaminergic
Mini-Reviews in Medicinal Chemistry
Title: Current Strategies for the Development of Novel Antipsychotic Drugs
Volume: 3 Issue: 3
Author(s): Jordi Bolos
Affiliation:
Keywords: Antipsychotic Drugs, D2 antagonism, dopamine receptor, neurotensin, glutamatergic, nondopaminergic
Abstract: While classical neuroleptics are characterized by dopamine D2 antagonism, this is also considered to be the cause of their neurological side effects. In recent years, novel antipsychotic drugs with improved efficacy, devoid of extrapyramidal effects are being developed. The mechanisms of action of these new atypical antipsychotics can be classified into three general groups: a) binding to D2 together with non-dopaminergic receptors, b) interaction with dopamine receptor subtypes other than D2 and c) selective binding to nondopaminergic systems, such as glutamatergic, sigma, neurotensin, and cannabinoid.
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Cite this article as:
Bolos Jordi, Current Strategies for the Development of Novel Antipsychotic Drugs, Mini-Reviews in Medicinal Chemistry 2003; 3 (3) . https://dx.doi.org/10.2174/1389557033488169
DOI https://dx.doi.org/10.2174/1389557033488169 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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