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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Crystallography of Membrane Proteins, Major Targets in Drug Design

Author(s): J. Wouters

Volume 3, Issue 5, 2003

Page: [439 - 448] Pages: 10

DOI: 10.2174/1389557033488015

Price: $65


Protein crystallography has the potential to accelerate drug discovery greatly. High-resolution structures of membrane proteins of pharmaceutical interest open new perspectives in drug design. Recent structural data obtained for cyclooxygenases, monoamine oxidase, squalene cyclase, rhodopsine, porins, aquaporins, and ABC transporters are presented and briefly discussed.

Keywords: membrane proteins crystallography

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