Abstract
Current anti-HIV drugs have extreme side effects and resistance to these drugs develops rapidly. The marine environment holds an unprecedented number of unusual chemical structural classes with activity against HIV. We review the literature on anti-HIV activity of marine natural products and discuss the efficacy of different structural classes.
Keywords: aids, hiv, marine natural products, structure-activity relationships, modified peptides, alkaloids
Mini-Reviews in Medicinal Chemistry
Title: Marine Natural Products as Lead Anti-HIV Agents
Volume: 3 Issue: 5
Author(s): D. J. Gochfeld, K. A. El Sayed, M. Yousaf, J. F. Hu, P. Bartyzel, D. C. Dunbar, S. P. Wilkins, J. K. Zjawiony, R. F. Schinazi and S. Schlueter Wirtz
Affiliation:
Keywords: aids, hiv, marine natural products, structure-activity relationships, modified peptides, alkaloids
Abstract: Current anti-HIV drugs have extreme side effects and resistance to these drugs develops rapidly. The marine environment holds an unprecedented number of unusual chemical structural classes with activity against HIV. We review the literature on anti-HIV activity of marine natural products and discuss the efficacy of different structural classes.
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Cite this article as:
Gochfeld J. D., El Sayed A. K., Yousaf M., Hu F. J., Bartyzel P., Dunbar C. D., Wilkins P. S., Zjawiony K. J., Schinazi F. R. and Wirtz Schlueter S., Marine Natural Products as Lead Anti-HIV Agents, Mini-Reviews in Medicinal Chemistry 2003; 3 (5) . https://dx.doi.org/10.2174/1389557033487962
DOI https://dx.doi.org/10.2174/1389557033487962 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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