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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Marine Natural Products as Lead Anti-HIV Agents

Author(s): D. J. Gochfeld, K. A. El Sayed, M. Yousaf, J. F. Hu, P. Bartyzel, D. C. Dunbar, S. P. Wilkins, J. K. Zjawiony, R. F. Schinazi and S. Schlueter Wirtz

Volume 3, Issue 5, 2003

Page: [401 - 424] Pages: 24

DOI: 10.2174/1389557033487962

Price: $65

Abstract

Current anti-HIV drugs have extreme side effects and resistance to these drugs develops rapidly. The marine environment holds an unprecedented number of unusual chemical structural classes with activity against HIV. We review the literature on anti-HIV activity of marine natural products and discuss the efficacy of different structural classes.

Keywords: aids, hiv, marine natural products, structure-activity relationships, modified peptides, alkaloids


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