Abstract
We here describe a new strategy for the delivery of oligonucleotides to cells that is based on the use of a short peptide containing three functional units: a membrane-penetrating segment, a DNA-binding domain and a cell-localization sequence. The designed vector binds strongly to oligonucleotides and has membrane-perturbing abilities in vitro. This type of multi-functional device may be a powerful tool to achieve efficient delivery of genetic drugs in vivo.
Keywords: antisense, oligonucleotides, drug-delivery, circular dichroism, fluorescence, liposomes, carboxyfluorescein, peptide device, genetic drug delivery
Protein & Peptide Letters
Title: Novel “Three-in-one” Peptide Device for Genetic Drug Delivery
Volume: 10 Issue: 1
Author(s): Jason Smith, Jesse Guidry and Pernilla Wittung-Stafshede
Affiliation:
Keywords: antisense, oligonucleotides, drug-delivery, circular dichroism, fluorescence, liposomes, carboxyfluorescein, peptide device, genetic drug delivery
Abstract: We here describe a new strategy for the delivery of oligonucleotides to cells that is based on the use of a short peptide containing three functional units: a membrane-penetrating segment, a DNA-binding domain and a cell-localization sequence. The designed vector binds strongly to oligonucleotides and has membrane-perturbing abilities in vitro. This type of multi-functional device may be a powerful tool to achieve efficient delivery of genetic drugs in vivo.
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Cite this article as:
Smith Jason, Guidry Jesse and Wittung-Stafshede Pernilla, Novel “Three-in-one” Peptide Device for Genetic Drug Delivery, Protein & Peptide Letters 2003; 10 (1) . https://dx.doi.org/10.2174/0929866033408291
DOI https://dx.doi.org/10.2174/0929866033408291 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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