Abstract
The search for new NK2 receptor antagonists have resulted in the discovery of several different classes of compounds with promise to have clinical utility. Clearly, the first reported non-peptide NK2 receptor antagonist (SR- 48,968) has inspired a lot of effort in the area, but over the years other approaches have also been fruitful. These include optimisation of hits from random screening and modifying compounds with NK3 receptor antagonistic properties into selective NK2 receptor antagonists. This is also an area where cyclic peptides and derivatives have been extensively examined. So far, no NK2 receptor antagonist has reached the market, but several clinical trials are in progress.
Keywords: nk2 receptor antagonists, nk2 receptor, sr- 48,968), decapeptide, neurokinin a
Current Topics in Medicinal Chemistry
Title: Recent Developments in the Medicinal Chemistry of NK2 Receptor Antagonists
Volume: 3 Issue: 12
Author(s): Anders Johansson
Affiliation:
Keywords: nk2 receptor antagonists, nk2 receptor, sr- 48,968), decapeptide, neurokinin a
Abstract: The search for new NK2 receptor antagonists have resulted in the discovery of several different classes of compounds with promise to have clinical utility. Clearly, the first reported non-peptide NK2 receptor antagonist (SR- 48,968) has inspired a lot of effort in the area, but over the years other approaches have also been fruitful. These include optimisation of hits from random screening and modifying compounds with NK3 receptor antagonistic properties into selective NK2 receptor antagonists. This is also an area where cyclic peptides and derivatives have been extensively examined. So far, no NK2 receptor antagonist has reached the market, but several clinical trials are in progress.
Export Options
About this article
Cite this article as:
Johansson Anders, Recent Developments in the Medicinal Chemistry of NK2 Receptor Antagonists, Current Topics in Medicinal Chemistry 2003; 3 (12) . https://dx.doi.org/10.2174/1568026033451835
DOI https://dx.doi.org/10.2174/1568026033451835 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
Call for Papers in Thematic Issues
Chemistry Based on Natural Products for Therapeutic Purposes
The development of new pharmaceuticals for a wide range of medical conditions has long relied on the identification of promising natural products (NPs). There are over sixty percent of cancer, infectious illness, and CNS disease medications that include an NP pharmacophore, according to the Food and Drug Administration. Since NP ...read more
Current Trends in Drug Discovery Based on Artificial Intelligence and Computer-Aided Drug Design
Drug development discovery has faced several challenges over the years. In fact, the evolution of classical approaches to modern methods using computational methods, or Computer-Aided Drug Design (CADD), has shown promising and essential results in any drug discovery campaign. Among these methods, molecular docking is one of the most notable ...read more
Drug Discovery in the Age of Artificial Intelligence
In the age of artificial intelligence (AI), we have witnessed a significant boom in AI techniques for drug discovery. AI techniques are increasingly integrated and accelerating the drug discovery process. These developments have not only attracted the attention of academia and industry but also raised important questions regarding the selection ...read more
From Biodiversity to Chemical Diversity: Focus of Flavonoids
Flavonoids are the largest group of polyphenols, plant secondary metabolites arising from the essential aromatic amino acid phenylalanine (or more rarely from tyrosine) via the phenylpropanoid pathway. The flavan nucleus is the basic 15-carbon skeleton of flavonoids (C6-C3-C6), which consists of two phenyl rings (A and B) and a heterocyclic ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
CatbNet: A Multi Network Analyzer for Comparing and Analyzing the Topology of Biological Networks
Current Genomics Role of Granulocyte-colony Stimulating Factor in the Protection of Cerebral Vascular Endothelium, White Matter, and Cognition
Current Neurovascular Research Preparation and Thermal Analysis of Flame-retardant Chitosan Thin Films on Ammonium Polyphosphate Treated Reconstituted Tobacco Sheet
Current Analytical Chemistry Pharmacological Approach of No-Reflow Phenomenon Related with Percutaneous Coronary Interventions
Cardiovascular & Hematological Agents in Medicinal Chemistry Preventative and Therapeutic Potential of Lipopolysaccharide Derived from Edible Gram-Negative Bacteria to Various Diseases
Current Drug Therapy Vaccine Therapy for Hepatitis B Virus Carrier
Current Drug Targets - Infectious Disorders Testosterone, Estradiol, and Sex Hormone-Binding Globulin in Alzheimer’s Disease: A Meta-Analysis
Current Alzheimer Research Morphological Segmentation Analysis and Texture-based Support Vector Machines Classification on Mice Liver Fibrosis Microscopic Images
Current Bioinformatics The Role of Signaling Pathway in the Biological Cause of Rheumatoid Arthritis
Current Drug Research Reviews Discovery of Nesfatin-1 and Overview of Biological Actions and New Developments
Current Pharmaceutical Design 10 Years of SELDI: What Have we Learnt?
Current Proteomics Mass Spectrometric Analysis of L-carnitine and its Esters: Potential Biomarkers of Disturbances in Carnitine Homeostasis
Current Molecular Medicine The Tachykinergic System as Avenues for Drug Intervention
Recent Patents on CNS Drug Discovery (Discontinued) HLA-G - From Fetal Tolerance to a Regulatory Molecule in Inflammatory Diseases
Current Immunology Reviews (Discontinued) Neuropathological Correlates of Falling in the CC75C Population-Based Sample of the Older Old
Current Alzheimer Research Opportunities and Challenges for Niosomes as Drug Delivery Systems
Current Drug Delivery Synthesis and Biological Activity of Hydrazones and Derivatives: A Review
Mini-Reviews in Medicinal Chemistry Toxin-Labeled Monoclonal Antibodies
Current Pharmaceutical Biotechnology Mitochondrial-Associated Metabolic Changes and Neurodegeneration in Huntingtons Disease - from Clinical Features to the Bench
Current Drug Targets An Overview on Potential Neuroprotective Compounds for Management of Alzheimer’s Disease
CNS & Neurological Disorders - Drug Targets