Proliferative Activity Of Neokyotorphinrelated Hemoglobin Fragments In Cell Cultures

Title: Proliferative Activity Of Neokyotorphinrelated Hemoglobin Fragments In Cell Cultures

Volume: 10 Issue: 4

Author(s): Olga V. Sazonova, Elena Yu. Blishchenko, Olga A. Kalinina, Natalya S. Egorova, Andrei Yu. Surovoy, Marina M. Philippova, Andrei A. Karelin and Vadim T. Ivanov

Affiliation:

Keywords: neokyotorphin, proliferation

Abstract: α-Hemoglobin fragments α-(133-141), α-(134-141), α-(135-141), α-(137-141), α-(134-140), α- (133-138), α-(134-140) and α-(137-138) stimulate L929 tumor cell proliferation, α-(134-141) being the most active. α-(134-141) stimulates proliferation of M3 melanoma cells, murine embryonic fibroblasts, primary cultures of red bone marrow and spleen cells. In L929 cells the effect of α-(134-141) is cell density independent; in M3 cells α-(137-141) and α-(134-141) are most active at density 10,000 cells / well (96 well plate) independently on FBS content.

Cite this article as:

Sazonova V. Olga, Blishchenko Yu. Elena, Kalinina A. Olga, Egorova S. Natalya, Surovoy Yu. Andrei, Philippova M. Marina, Karelin A. Andrei and Ivanov T. Vadim, Proliferative Activity Of Neokyotorphinrelated Hemoglobin Fragments In Cell Cultures, Protein & Peptide Letters 2003; 10 (4) . https://dx.doi.org/10.2174/0929866033478780