Abstract
Thyroid hormone regulates many important processes in vertebrates. Analysis of the symptoms that accompany hypo- and hyperthyroidism, the most common disorders of the thyroid, suggests that there are certain desirable biological effects brought about by an excess or deficiency of thyroid hormone, and that selective thyroid hormone receptor modulators (STRMs) would be potentially useful therapeutic agents. This review will provide an introduction to thyroid hormone biology, and will discuss the chemistry and pharmacology of the first generation STRMs.
Keywords: thyroid hormone receptor modulators, hyperthyroidism, strms
Current Topics in Medicinal Chemistry
Title: Selective Thyroid Hormone Receptor Modulators
Volume: 3 Issue: 14
Author(s): Hikari A.I. Yoshihara and Thomas S. Scanlan
Affiliation:
Keywords: thyroid hormone receptor modulators, hyperthyroidism, strms
Abstract: Thyroid hormone regulates many important processes in vertebrates. Analysis of the symptoms that accompany hypo- and hyperthyroidism, the most common disorders of the thyroid, suggests that there are certain desirable biological effects brought about by an excess or deficiency of thyroid hormone, and that selective thyroid hormone receptor modulators (STRMs) would be potentially useful therapeutic agents. This review will provide an introduction to thyroid hormone biology, and will discuss the chemistry and pharmacology of the first generation STRMs.
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Cite this article as:
Yoshihara A.I. Hikari and Scanlan S. Thomas, Selective Thyroid Hormone Receptor Modulators, Current Topics in Medicinal Chemistry 2003; 3 (14) . https://dx.doi.org/10.2174/1568026033451682
DOI https://dx.doi.org/10.2174/1568026033451682 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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