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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Iminosugars and Relatives as Antiviral and Potential Anti-infective Agents

Author(s): P. Greimel, J. Spreitz, A. E. Stutz and T. M. Wrodnigg

Volume 3, Issue 5, 2003

Page: [513 - 523] Pages: 11

DOI: 10.2174/1568026033452456

Price: $65


Iminosugars have emerged in the literature during mid-1960s as synthetic compounds. Around the same time, the first examples were found in Nature and their interesting enzyme inhibitory properties were recognised. Due to their powerful interference with glycohydrolases (glycosidases) as well as glycosyltransferases, quite a few representatives exhibit notable biological activities. These range from antidiabetic, insect antifeedant, nematicidal, plant growth regulating to immunomodulating, anti-cancer as well as - in selected cases - anti-infective properties. The latter will be the focus of the following survey.

Keywords: iminosugar, iminoalditol, antiinfective, antiviral, antibacterial, antifungal, antiprotozoan

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