Abstract
This review is organized in three parts: firstly there is a general overview of recent developments in lipophilicity written to induce medicinal chemists to question what they want to obtain from this kind of study; secondly, the state-of-the-art of experimental and computational determination of log P is briefly reviewed; finally, some applications are discussed to illustrate how much information can be extracted from lipophilicity, and to highlight the difficulty of obtaining a reliable, general method to work with.
Keywords: log p, log d, partitioning system, clogp, distribution profile, folding
Mini-Reviews in Medicinal Chemistry
Title: A Comparison of Calculated and Experimental Parameters as Sources of Structural Information: The Case of Lipophilicity-Related Descriptors
Volume: 3 Issue: 8
Author(s): Giulia Caron and Giuseppe Ermondi
Affiliation:
Keywords: log p, log d, partitioning system, clogp, distribution profile, folding
Abstract: This review is organized in three parts: firstly there is a general overview of recent developments in lipophilicity written to induce medicinal chemists to question what they want to obtain from this kind of study; secondly, the state-of-the-art of experimental and computational determination of log P is briefly reviewed; finally, some applications are discussed to illustrate how much information can be extracted from lipophilicity, and to highlight the difficulty of obtaining a reliable, general method to work with.
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Cite this article as:
Caron Giulia and Ermondi Giuseppe, A Comparison of Calculated and Experimental Parameters as Sources of Structural Information: The Case of Lipophilicity-Related Descriptors, Mini-Reviews in Medicinal Chemistry 2003; 3 (8) . https://dx.doi.org/10.2174/1389557033487665
DOI https://dx.doi.org/10.2174/1389557033487665 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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