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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

A Comparison of Calculated and Experimental Parameters as Sources of Structural Information: The Case of Lipophilicity-Related Descriptors

Author(s): Giulia Caron and Giuseppe Ermondi

Volume 3, Issue 8, 2003

Page: [821 - 830] Pages: 10

DOI: 10.2174/1389557033487665

Price: $65


This review is organized in three parts: firstly there is a general overview of recent developments in lipophilicity written to induce medicinal chemists to question what they want to obtain from this kind of study; secondly, the state-of-the-art of experimental and computational determination of log P is briefly reviewed; finally, some applications are discussed to illustrate how much information can be extracted from lipophilicity, and to highlight the difficulty of obtaining a reliable, general method to work with.

Keywords: log p, log d, partitioning system, clogp, distribution profile, folding

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