Recent Progress in the Design of Selectin Inhibitors

Title: Recent Progress in the Design of Selectin Inhibitors

Volume: 3 Issue: 7

Author(s): Siri Ram Chhabra, Aisyah S. Abdul Rahim and Barrie Kellam

Affiliation:

Keywords: selectins, sialyl lewis, adhesion molecules, antagonist, mimetics, inflammation

Abstract: The selectins are a family of cell-adhesion proteins that mediate the early stages of leukocyte recruitment from the blood stream to sites of tissue damage through recognition of the carbohydrate epitope sialyl Lewis-x (sLe-x). Current development of small molecule based inhibitors of this process and their clinical potential to address numerous acute and chronic diseases are explored.

Cite this article as:

Chhabra Ram Siri, Rahim S. Abdul Aisyah and Kellam Barrie, Recent Progress in the Design of Selectin Inhibitors, Mini-Reviews in Medicinal Chemistry 2003; 3(7) . https://dx.doi.org/10.2174/1389557033487791