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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Recent Progress in the Design of Selectin Inhibitors

Author(s): Siri Ram Chhabra, Aisyah S. Abdul Rahim and Barrie Kellam

Volume 3, Issue 7, 2003

Page: [679 - 687] Pages: 9

DOI: 10.2174/1389557033487791

Price: $65


The selectins are a family of cell-adhesion proteins that mediate the early stages of leukocyte recruitment from the blood stream to sites of tissue damage through recognition of the carbohydrate epitope sialyl Lewis-x (sLe-x). Current development of small molecule based inhibitors of this process and their clinical potential to address numerous acute and chronic diseases are explored.

Keywords: selectins, sialyl lewis, adhesion molecules, antagonist, mimetics, inflammation

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