Generic placeholder image

CNS & Neurological Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5273
ISSN (Online): 1996-3181

Neurological Disorders in Mice Lacking Glycogenes that are Mainly Expressed in Brain

Author(s): Hisashi Narimatsu

Volume 5, Issue 4, 2006

Page: [441 - 444] Pages: 4

DOI: 10.2174/187152706777950747

Price: $65

Abstract

At the present time, 160 human glycogenes encoding glycosyltransferases and sulfotransferases, which add sulfate to carbohydrates, have been cloned and analyzed for their substrate specificity. Mice have almost all genes orthologous to them, and some are specifically expressed in neuronal tissues. In this review, neurological disorders of mice deficient for the glycogenes that synthesize interesting carbohydrate epitopes in neuronal tissues are described and summarized.

Keywords: Glycogene, glycosyltransferase, sulfotransferase, ganglioside, HNK-1, Lewis X, polysialic acid, knockout mouse


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy