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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

7-Keto-Δ5-Steroids: Key-Molecules Owning Particular Biological and Chemical Interest

Author(s): E. S. Arsenou, M. A. Fousteris, A. I. Koutsourea and S. S. Nikolaropoulos

Volume 3, Issue 6, 2003

Page: [557 - 567] Pages: 11

DOI: 10.2174/1389557033487953

Price: $65


7-keto-Δ5-steroids have been suggested for the treatment of several diseases. Their significant biological profile resulted in the development of a great number of methods and reagents for the allylic oxidation of Δ5-steroids. These methods and the biological evaluation of the main oxidized Δ5-steroids are summarized.

Keywords: 7-keto-, allylic oxidation, 7-keto-cholesterol, 7-keto-dhea, anticancer activity, aromatase inhibitors, apoptosis

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