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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Factors Determining The Efficacy Of Alphahelical Antimicrobial Peptides

Author(s): Sarah R. Dennison, Frederick Harris and David A. Phoenix

Volume 10, Issue 5, 2003

Page: [497 - 502] Pages: 6

DOI: 10.2174/0929866033478663

Price: $65

Abstract

A database of α-helical antimicrobial peptides (AMP) was established and their minimum inhibitory concentrations (MIC) were compared with their physiochemical characteristics in an attempt to establish those features that determine efficacy. There is no significant difference in AMP sensitivity between Gram-positive and Gram-negative bacteria but fungi did require higher concentrations to achieve the same degree of growth inhibition. For antibacterial peptides there appears to be a positive correlation between MIC and hydrophobic arc size and a negative correlation between MIC and net charge.

Keywords: Antimicrobial Peptides, Gram-negative bacteria, fungi, hydrophobic arc


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