Factors Determining The Efficacy Of Alphahelical Antimicrobial Peptides

Sarah   R.   Dennison; Frederick      Harris; David   A.   Phoenix

doi:10.2174/0929866033478663

Abstract

A database of α-helical antimicrobial peptides (AMP) was established and their minimum inhibitory concentrations (MIC) were compared with their physiochemical characteristics in an attempt to establish those features that determine efficacy. There is no significant difference in AMP sensitivity between Gram-positive and Gram-negative bacteria but fungi did require higher concentrations to achieve the same degree of growth inhibition. For antibacterial peptides there appears to be a positive correlation between MIC and hydrophobic arc size and a negative correlation between MIC and net charge.

Keywords: Antimicrobial Peptides, Gram-negative bacteria, fungi, hydrophobic arc

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Protein & Peptide Letters

Title: Factors Determining The Efficacy Of Alphahelical Antimicrobial Peptides

Volume: 10 Issue: 5

Author(s): Sarah R. Dennison, Frederick Harris and David A. Phoenix

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Keywords: Antimicrobial Peptides, Gram-negative bacteria, fungi, hydrophobic arc

Abstract: A database of α-helical antimicrobial peptides (AMP) was established and their minimum inhibitory concentrations (MIC) were compared with their physiochemical characteristics in an attempt to establish those features that determine efficacy. There is no significant difference in AMP sensitivity between Gram-positive and Gram-negative bacteria but fungi did require higher concentrations to achieve the same degree of growth inhibition. For antibacterial peptides there appears to be a positive correlation between MIC and hydrophobic arc size and a negative correlation between MIC and net charge.

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Cite this article as:

Dennison R. Sarah, Harris Frederick and Phoenix A. David, Factors Determining The Efficacy Of Alphahelical Antimicrobial Peptides, Protein & Peptide Letters 2003; 10 (5) . https://dx.doi.org/10.2174/0929866033478663

DOI https://dx.doi.org/10.2174/0929866033478663	Print ISSN 0929-8665
Publisher Name Bentham Science Publisher	Online ISSN 1875-5305

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