Abstract
Hsp104p, as an anti-oxidative protector of ROS generation, was examined to inquire if it prevents aggregation of synuclein mutants, A30P or A53T upon aging, in vitro. The role of Hsp104p was also addressed in dissociation of pre-formed aggregates of synuclein mutants. Significant protection in fibril formation was observed by wild-type Hsp104p regardless of ATP presence, not by mutant Hsp104p. To a lesser extent, the dissociation effect of wild-type Hsp104p was observed only in the presence of ATP. These results will be discussed in relation to the development of an antioxidant approach to prevent amyloid fibril formation in several neurodegenerative diseases.
Keywords: hsp104p, molecular chaperone, synuclein, aggregation
Protein & Peptide Letters
Title: Regulation Of In Vitro Fibril Formation Of Synuclein Mutant Proteins By Hsp104p
Volume: 10 Issue: 5
Author(s): Byungmoon Kong, Young Kee Chae and Kyunghee Lee
Affiliation:
Keywords: hsp104p, molecular chaperone, synuclein, aggregation
Abstract: Hsp104p, as an anti-oxidative protector of ROS generation, was examined to inquire if it prevents aggregation of synuclein mutants, A30P or A53T upon aging, in vitro. The role of Hsp104p was also addressed in dissociation of pre-formed aggregates of synuclein mutants. Significant protection in fibril formation was observed by wild-type Hsp104p regardless of ATP presence, not by mutant Hsp104p. To a lesser extent, the dissociation effect of wild-type Hsp104p was observed only in the presence of ATP. These results will be discussed in relation to the development of an antioxidant approach to prevent amyloid fibril formation in several neurodegenerative diseases.
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Cite this article as:
Kong Byungmoon, Chae Kee Young and Lee Kyunghee, Regulation Of In Vitro Fibril Formation Of Synuclein Mutant Proteins By Hsp104p, Protein & Peptide Letters 2003; 10 (5) . https://dx.doi.org/10.2174/0929866033478717
DOI https://dx.doi.org/10.2174/0929866033478717 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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