Abstract
Monoamine oxidase (MAO) inhibitors were developed as antidepressants but many drugs, including the novel oxazolidinone antibacterial agents, share similar molecular properties and have MAO inhibitory activity. Factors important for binding antidepressants and modifications to decrease binding of oxazolidinones to avoid undesirable vascular effects are discussed.
Keywords: monoamine oxidase, mao, mao inhibitor, monoamine oxidase inhibitor, antidepressants, oxazolidinones
Mini-Reviews in Medicinal Chemistry
Title: Monoamine Oxidases: to Inhibit or Not to Inhibit
Volume: 3 Issue: 2
Author(s): R. R. Ramsay and M. B. Gravestock
Affiliation:
Keywords: monoamine oxidase, mao, mao inhibitor, monoamine oxidase inhibitor, antidepressants, oxazolidinones
Abstract: Monoamine oxidase (MAO) inhibitors were developed as antidepressants but many drugs, including the novel oxazolidinone antibacterial agents, share similar molecular properties and have MAO inhibitory activity. Factors important for binding antidepressants and modifications to decrease binding of oxazolidinones to avoid undesirable vascular effects are discussed.
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Cite this article as:
Ramsay R. R. and Gravestock B. M., Monoamine Oxidases: to Inhibit or Not to Inhibit, Mini-Reviews in Medicinal Chemistry 2003; 3 (2) . https://dx.doi.org/10.2174/1389557033405287
DOI https://dx.doi.org/10.2174/1389557033405287 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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