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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Synthesis of New Ligands Derived from Polyphosphonates Partial Esters

Author(s): Pascale Even, Erwann Guenin, Mounya Benramdame, Patricia Quidu, Driss El Manouni and Marc Lecouvey

Volume 1, Issue 1, 2004

Page: [75 - 77] Pages: 3

DOI: 10.2174/1570178043488563


In the search for new chelation therapy drugs for the treatment of metal intoxications, some new polyphosphonated chelating ligands have been synthesized. They were obtained by means of an Arbuzov reaction followed by addition of the corresponding dialkylphosphite. The regioselective dealkylation was then carried out by using trimethylsilyl halide.

Keywords: tetraphosphonate, chelating agents, restrained geometry, partial deprotection

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