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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Immunotoxins and Other Conjugates: Pre-clinical Studies

Author(s): A. Bolognesi and L. Polito

Volume 4, Issue 5, 2004

Page: [563 - 583] Pages: 21

DOI: 10.2174/1389557043403864

Price: $65


A wide variety of conjugates containing RIPs, of either chemical or recombinant type, have been made and tested against dangerous cells in vitro and in animal models. Many of these pre-clinical studies will be reviewed here dividing them on the basis of the target cell and the surface molecule specifically recognized.

Keywords: ribosome-inactivating proteins, toxins, conjugates, immunotoxins, targeting, immunotherapy

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