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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Genetics of Ribosome-Inactivating Proteins

Author(s): Martin R. Hartley and J. Michael Lord

Volume 4, Issue 5, 2004

Page: [487 - 492] Pages: 6

DOI: 10.2174/1389557043403828

Price: $65

Abstract

Ribosome-inactivating proteins (RIPs) are a heterogeneous group of enzymes found mainly in plants and a few bacteria that possess N-glycosidase activity on ribosomes and a related polynucleotide adenosine glycosidase activity on naked nucleic acids. They encompass single enzymatic chains, heterodimeric toxic lectins and related agglutinins. Plants commonly produce several RIP isoforms encoded by multi-gene families. The toxic lectins possess adaptations related to their cytotoxic role.

Keywords: ribosome-inactivating protein, ricin, pokeweed antiviral protein, rna n-glycosidase


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