Abstract
Ribosome-inactivating proteins (RIPs) are a heterogeneous group of enzymes found mainly in plants and a few bacteria that possess N-glycosidase activity on ribosomes and a related polynucleotide adenosine glycosidase activity on naked nucleic acids. They encompass single enzymatic chains, heterodimeric toxic lectins and related agglutinins. Plants commonly produce several RIP isoforms encoded by multi-gene families. The toxic lectins possess adaptations related to their cytotoxic role.
Keywords: ribosome-inactivating protein, ricin, pokeweed antiviral protein, rna n-glycosidase
Mini-Reviews in Medicinal Chemistry
Title: Genetics of Ribosome-Inactivating Proteins
Volume: 4 Issue: 5
Author(s): Martin R. Hartley and J. Michael Lord
Affiliation:
Keywords: ribosome-inactivating protein, ricin, pokeweed antiviral protein, rna n-glycosidase
Abstract: Ribosome-inactivating proteins (RIPs) are a heterogeneous group of enzymes found mainly in plants and a few bacteria that possess N-glycosidase activity on ribosomes and a related polynucleotide adenosine glycosidase activity on naked nucleic acids. They encompass single enzymatic chains, heterodimeric toxic lectins and related agglutinins. Plants commonly produce several RIP isoforms encoded by multi-gene families. The toxic lectins possess adaptations related to their cytotoxic role.
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Cite this article as:
Hartley R. Martin and Lord Michael J., Genetics of Ribosome-Inactivating Proteins, Mini-Reviews in Medicinal Chemistry 2004; 4 (5) . https://dx.doi.org/10.2174/1389557043403828
DOI https://dx.doi.org/10.2174/1389557043403828 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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