The Structure of Ribosome Inactivating Proteins

Jon   D.   Robertus; Arthur   F.   Monzingo

Abstract

Ribosome Inactivating Proteins, RIPs, depurinate an invariant adenine from the 28S rRNA of eukaryotic ribosomes; they have evolved to near enzymatic perfection for this task. The N-glycosidase fold is conserved in plant and bacterial enzymes. RIPs can form complexes with cell surface recognition proteins that dramatically increase the cytotoxicity of the molecule.

Keywords: ribosome inactivating proteins, 28s rrna, eukaryotic ribosomes

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Mini-Reviews in Medicinal Chemistry

Title: The Structure of Ribosome Inactivating Proteins

Volume: 4 Issue: 5

Author(s): Jon D. Robertus and Arthur F. Monzingo

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Keywords: ribosome inactivating proteins, 28s rrna, eukaryotic ribosomes

Abstract: Ribosome Inactivating Proteins, RIPs, depurinate an invariant adenine from the 28S rRNA of eukaryotic ribosomes; they have evolved to near enzymatic perfection for this task. The N-glycosidase fold is conserved in plant and bacterial enzymes. RIPs can form complexes with cell surface recognition proteins that dramatically increase the cytotoxicity of the molecule.

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Robertus D. Jon and Monzingo F. Arthur, The Structure of Ribosome Inactivating Proteins, Mini-Reviews in Medicinal Chemistry 2004; 4 (5) . https://dx.doi.org/10.2174/1389557043403837

DOI https://dx.doi.org/10.2174/1389557043403837	Print ISSN 1389-5575
Publisher Name Bentham Science Publisher	Online ISSN 1875-5607

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