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Current Organic Synthesis


ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

4-Alkoxy-1,1,1-Trichloro-3-Alken-2-ones: Preparation and Applications in Heterocyclic Synthesis

Author(s): Marcos A. P. Martins, Wilson Cunico, Claudio M. P. Pereira, Adilson P. Sinhorin, Alex F. C. Flores, Helio G. Bonacorso and Nilo Zanatta

Volume 1, Issue 4, 2004

Page: [391 - 403] Pages: 13

DOI: 10.2174/1570179043366611

Price: $65


The preparation of 4-alkoxy-1,1,1-trichloro-3-alken-2-ones (enones), important synthetic tools for the heterocyclic synthesis, from cheap and easily accessible starting materials, is reported. The applications of the enones in the synthesis of isoxazoles, pyrazoles, pyrimidines and other heterocycles are also reported. This review was grouped into two main sections: (i) synthesis of 4-alkoxy-1,1,1-trichloro-3-alken-2-ones and derivatives and (ii) applications of 4-alkoxy-1,1,1-trichloro-3-alken-2-ones in heterocyclic synthesis.

Keywords: enones, enol ethers, acetals, trichloromethyl-compounds, isoxazoles, pyrazoles, pyrimidines

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