Generic placeholder image

Current Organic Synthesis


ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

Synthesis of Anti-Angiogenic Isocoumarins

Author(s): Haiqing Yuan, Bernd Junker, Paul Helquist and Richard E. Taylor

Volume 1 , Issue 1 , 2004

Page: [1 - 9] Pages: 9

DOI: 10.2174/1570179043485411


A concise synthetic route has been developed for the preparation of the naturally occurring isocoumarin cytogenin and NM-3, an analogue with anti-angiogenic activity. The route is general and also provided C(3) side chain modified analogues. Key aspects of the synthesis include orthogonal protection of the two aromatic alkoxy groups, benzylic lithiation and carboxylation, use of the resulting carboxylic acid in a DCC-promoted acylation of Meldrums acid, and facile ester enolate alkylations for introduction of side chains for convenient generation of a new set of NM-3 analogues.

Keywords: anti-angiogenic, cytogenin, benzylic lithiation, ester enolate alkylation, isocoumarins, NM-3

© 2022 Bentham Science Publishers | Privacy Policy