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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

New Developments on Thromboxane Modulators

Author(s): Jean-Michel Dogne, Julien Hanson, Xavier de Leval, Bernard Masereel, Philippe Kolh and Bernard Pirotte

Volume 4 , Issue 6 , 2004

Page: [649 - 657] Pages: 9

DOI: 10.2174/1389557043403684

Price: $65


Thromboxane A2 (TXA2) is a labile product formed from arachidonic acid by cyclooxygenase. The pathogenesis of numerous cardiovascular, pulmonary, and thromboembolic diseases can be related to this metabolite. Therefore, TXA2 modulators have been developed for 20 years. This review will highlight the evolution in the field of TXA2 modulators.

Keywords: thromboxane a2, arachidonic acid, thromboxane synthase, prostanoids

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