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Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Dine (Damage-Induced Neuronal Endopeptidase)

Author(s): Sumiko Kiryu-Seo and Hiroshi Kiyama

Volume 11, Issue 5, 2004

Page: [451 - 460] Pages: 10

DOI: 10.2174/0929866043406526

Price: $65


A unique central nervous system (CNS)-specific metalloprotease, DINE / ECEL1 (damage induced neuronal endopeptidase / endothelin converting enzyme-like 1), has recently been added to the M13 / neprilysin (NEP) family. This enzyme was identified by two groups independently using different approaches. In this review, we introduce the characteristics of DINE / ECEL1 and focus on the mechanism underlying the transcriptional regulation of DINE in response to neuronal injury.

Keywords: dine, ecel1, neprilysin, neuron, nerve injury, survival, neuropeptides, leukemia inhibitory, factor (lif)

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