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Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Cytosolic Insulin-Binding Proteins Of Mouse Liver Cells

Author(s): Petr G. Lokhov, Sergei A. Moshkovskii, Olga M. Ipatova and Vladimir N. Prozorovskii

Volume 11 , Issue 1 , 2004

Page: [29 - 33] Pages: 5

DOI: 10.2174/0929866043478356

Price: $65


It has been recently shown that insulin retains its biological activity after receptor-directed internalization and it may affect the cell metabolism by interaction with cytosolic insulin-binding proteins (CIBPs). Using affinity chromatography combined with SDS-PAGE and MALDI-TOF mass-spectrometry we have identified 7 proteins from mouse liver cells that specifically bind to the insulin, including adenylate kinase 2 (25.6 kD), kinesin superfamily protein 20B (26.0 kD), hepatic arginase 1 (34.8 kD), fructosebisphosphate aldolase B (39.5 kD), 4-hydroxyphenylpyruvate dioxygenase (45.1 kD), betainehomocysteine methyl-transferase (45.0 kD) and KRIT1 (83.4 kD).

Keywords: insulin-binding protein, affinity chromatography, cytosol, liver cells

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