Abstract
Chemogenomics is a gene family-based approach to drug discovery and target validation. This review will summarize the application of this interdisciplinary approach to the protein kinases of the human genome with emphasis upon the synergies and efficiencies to be gained. Specific examples from the SAPKfamily will be discussed.
Keywords: chemogenomics, kinases, structure-based drug design
Mini-Reviews in Medicinal Chemistry
Title: Kinase Chemogenomics: Targeting the Human Kinome for Target Validation and Drug Discovery
Volume: 4 Issue: 3
Author(s): E. ter Haar, W. P. Walters, S. Pazhanisamy, P. Taslimi, A. C. Pierce, G. W. Bemis, F. G. Salituro and S. L. Harbeson
Affiliation:
Keywords: chemogenomics, kinases, structure-based drug design
Abstract: Chemogenomics is a gene family-based approach to drug discovery and target validation. This review will summarize the application of this interdisciplinary approach to the protein kinases of the human genome with emphasis upon the synergies and efficiencies to be gained. Specific examples from the SAPKfamily will be discussed.
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Cite this article as:
Haar ter E., Walters P. W., Pazhanisamy S., Taslimi P., Pierce C. A., Bemis W. G., Salituro G. F. and Harbeson L. S., Kinase Chemogenomics: Targeting the Human Kinome for Target Validation and Drug Discovery, Mini-Reviews in Medicinal Chemistry 2004; 4 (3) . https://dx.doi.org/10.2174/1389557043487367
DOI https://dx.doi.org/10.2174/1389557043487367 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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