Abstract
Excessive hepatic glucose production is thought to be a major contributor to the type 2 diabetic state. Drug discovery efforts have yielded small synthetic inhibitors for gluconeogenic and glycogenic regulators of this pathway. The most advanced targets are outlined in this mini-review and include: the glucocorticoid receptor, 11β-hydroxysteroid dehydrogenase type 1, fructose 1,6-bisphosphatase, the glucagon receptor, glycogen phosphorylase, glycogen synthase kinase-3, and glucose-6-phosphatase.
Keywords: glucocorticoid receptor, f16bpase, glycogen phosphorylase, glucagon receptor, gsk-3, g6pase
Mini-Reviews in Medicinal Chemistry
Title: Intervention of Hepatic Glucose Production. Small Molecule Regulators of Potential Targets for Type 2 Diabetes Therapy
Volume: 4 Issue: 8
Author(s): Tjeerd Barf
Affiliation:
Keywords: glucocorticoid receptor, f16bpase, glycogen phosphorylase, glucagon receptor, gsk-3, g6pase
Abstract: Excessive hepatic glucose production is thought to be a major contributor to the type 2 diabetic state. Drug discovery efforts have yielded small synthetic inhibitors for gluconeogenic and glycogenic regulators of this pathway. The most advanced targets are outlined in this mini-review and include: the glucocorticoid receptor, 11β-hydroxysteroid dehydrogenase type 1, fructose 1,6-bisphosphatase, the glucagon receptor, glycogen phosphorylase, glycogen synthase kinase-3, and glucose-6-phosphatase.
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Cite this article as:
Barf Tjeerd, Intervention of Hepatic Glucose Production. Small Molecule Regulators of Potential Targets for Type 2 Diabetes Therapy, Mini-Reviews in Medicinal Chemistry 2004; 4 (8) . https://dx.doi.org/10.2174/1389557043403459
DOI https://dx.doi.org/10.2174/1389557043403459 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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