New Drug Design for Gene Therapy - Taking Advantage of Introns

Title: New Drug Design for Gene Therapy - Taking Advantage of Introns

Volume: 1 Issue: 3

Author(s): Shi-Lung Lin and Shao-Yao Ying

Affiliation:

Keywords: artificial intron, posttranscriptional gene silencing, pol-II-directed rna interference (rnai), d-rnai, mirna generation, rna splicing, intron-mediated enhancement (ime)

Abstract: A novel gene modulation system was identified within mammalian introns, regulating intracellular gene transcripts homologous to certain 5-proximal non-snRNP-binding regions of spliced introns. This gene modulation system can be manipulated for the analysis of gene function and development of gene-specific therapeutics, using artificial introns with 5-proximal hairpin inserts.

Cite this article as:

Lin Shi-Lung and Ying Shao-Yao, New Drug Design for Gene Therapy - Taking Advantage of Introns, Letters in Drug Design & Discovery 2004; 1 (3) . https://dx.doi.org/10.2174/1570180043398939