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Letters in Drug Design & Discovery


ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Armed Imidazo [1,2-a] Pyrimidines (Pyridines): Evaluation of Antibacterial Activity

Author(s): A. Anaflous, N. Benchat, M. Mimouni, S. Abouricha, T. Ben-Hadda, B. El-Bali, A. Hakkou and B. Hacht

Volume 1, Issue 3, 2004

Page: [224 - 229] Pages: 6

DOI: 10.2174/1570180043398885

Price: $65


Imidazopyridines and imidazopyrimidines have been prepared and tested for their antibacterial activity in vitro. Structure activity relationship studies indicate (SAR) that a modulation of both natures of arm in position 3 and atom in position 8 of these compounds has a direct impact on the antibacterial activity.

Keywords: Imidazo[1,2-a]pyrimidines., imidazo[1,2-a]pyridines, antibacterial agents, functionalised arms, n-ligands, mycobacterium tuberculosis

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