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Current Pharmacogenomics


ISSN (Print): 1570-1603
ISSN (Online): 1570-1603

Saccharomyces Cerevisiae as a Genetic Model in Anticancer Therapy

Author(s): J. E. Kurtz, P. Dufour, J. P. Bergerat and F. Exinger

Volume 3, Issue 1, 2005

Page: [1 - 7] Pages: 7

DOI: 10.2174/1570160053175045

Price: $65


With the recent sequencing of its entire genome, the yeast Saccharomyces cerevisiae has gained considerable interest in the field of anticancer research. The genetic properties of the yeast allow easy selection of a variety of mutants, as their related phenotypes provide valuable information on anticancer drugs effects in vivo. Moreover, the yeast has been extensively studied as a model system to decipher basic cellular processes that are well conserved from yeast to human and implicated in cancer establishment and progression. We discuss the advantages of Saccharomyces cerevisiae for investigating the metabolism of pyrimidines, a major target for anticancer chemotherapy. We also emphasize the links between basic science in the pyrimidine metabolism and new anticancer antimetabolites as well as future prospects in this field.

Keywords: saccharomyces cerevisiae, cancer, chemotherapy, pyrimidine metabolism

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