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Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Oxytocin and Its Analogs, Methyl-Substituted in Ortho-, Meta- or Para- Position of Aromatic Ring of Phenylalanine in Position 2: NMR Study and Biological Activities

Author(s): Milos Budesinsky, Zdenko Prochazka and Jirina Slaninova

Volume 12, Issue 4, 2005

Page: [343 - 347] Pages: 5

DOI: 10.2174/0929866053765752

Price: $65


Complete analyses of NMR data of oxytocin (OT) and 4 analogues, ([o-MePhe2]OT, [mMe-Phe2]OT, [m- OMePhe2]OT and [p-MePhe2]OT), are given. The same conformational behavior in solution on one hand and large differences in biological activities on the other hand indicate that the compounds adopt a “biologically active conformation” at the stage of interaction with the receptor when the character of the substituent and its position on the aromatic ring may play a role in hindering attaining the ideal complementarity of both interacting components.

Keywords: oxytocin, analogues, nmr, biological activity

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