Enantiopure Bicyclic Piperidinones: Stereocontrolled Cycloadditions

Title: Enantiopure Bicyclic Piperidinones: Stereocontrolled Cycloadditions

Volume: 2 Issue: 1

Author(s): A. G. Brewster, S. Broady, E. Glenn, S. A. Hermitage, M. Hughes, M. G. Moloney and G. Woods

Affiliation:

Keywords: piperidinones, conjugate additions, lewis acid catalysis

Abstract: The cycloadditions of a [4.3.0]-bicyclic α,β-unsaturated lactam, derived from 6-oxopipecolic acid, have been investigated. Although yields are modest, diastereoselectivity is high; reasons for the low reactivity are postulated, based on experimental observations and molecular modelling.

Cite this article as:

Brewster G. A., Broady S., Glenn E., Hermitage A. S., Hughes M., Moloney G. M. and Woods G., Enantiopure Bicyclic Piperidinones: Stereocontrolled Cycloadditions, Letters in Organic Chemistry 2005; 2 (1) . https://dx.doi.org/10.2174/1570178053400270